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Imatinib at 400 mg twice daily had an inhibitory effect on cyp2d6-mediated metoprolol metabolism, with metoprolol c and auc being increased by approximately 23 (90ci 1. The most commonly reported ( 10) drug- related adverse reactions in both settings were mild nausea, vomiting, diarrhoea, abdominal pain, fatigue, myalgia, muscle cramps and rash...

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